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1. ¶ÁÕßÏ£ÍûÔÚ¾ä×ӵĿªÊ¼¿´µ½ÊìϤµÄÐÅÏ¢¡£¾ä×ÓÊÇÎÄÕµÄ×îС¹¦Äܵ¥Ôª¡£×îÈÝÒ×Àí½âµÄ¾ä×ÓÊÇÕû¾ä¶¼ÔÚ˵¶ÁÕßÖªµÀµÄ¶«Î÷¡£µ«Õâ¶Ô¿Æ¼¼ÂÛÎÄÊDz»¿ÉÄܵģ¬ÒòΪֻÓÐÐµĶ«Î÷²Å»á±»·¢±í¡£ÊÂʵÉϿƼ¼ÂÛÎÄͨ³£»á°üº¬ºÜ¶àÐÂÊõÓËùÒÔÒ»¸öÈÝÒ×Àí½âµÄ¾ä×ÓÓ¦¸Ã´Ó¶ÁÕßÊìϤµÄÐÅÏ¢£¨»ò¸Õ¸ÕÌá¹ýµÄ£©¿ªÊ¼¶øÒÔÐÂÐÅÏ¢½áÊø£¬²¢ÔÚËüÃÇÖ®¼äƽ»¬µØ¹ý¶É¡£ºÃÎÄÕµÄËùÓоä×Ó¶¼Ó¦¸ÃÕâÑù´Ó¾Éµ½ÐÂµØÆ½»¬¹ý¶É¡£Ð´ºÃÒ»¾ä¿ªÍ·µÄ½ð¿ÆÓñÂÉÊÇÎÊÎÊÄã×Ô¼º£º¡°ÎÒÒÔǰÓÐûÓÐÌá¹ýÕâ¸ö¸ÅÄ¡±´ó¶àÊýÎÄÕºÜÄѶÁÊÇÒòΪºÜ¶àиÅÄîÔÚûÓб»½éÉÜ֮ǰ¾ÍʹÓÃÁË¡£ÀýÈ磺Samples for the 2-dimensional projection of kinetic trajectories are shown in Figure 7. The coil states are loosely gathered while the native states can form a black cluster with extremely high density in the 2-dimensional projection plane.
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Kinetic trajectories are projected onto xx and yy variables in Figure 7. This figure shows two populated states. One corresponds to loosely gathered coil states while the other is the native state with a higher density.
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The accuracy of the model structures is given by TM-score. In case of a perfect match to the experimental structure, TM-score would be 1.
ÔÚµÚ¶þ¸ö¾ä×ÓÀ¾ÉÐÅÏ¢¡°TM-score¡±±»ÂñÔÚÖм䣬±»ÐÂÐÅÏ¢¡°a perfect match to experimental structure ¡±´ò¶ÏÁË¡£ÕâÀィÒéÐÞ¸ÄÈçÏ£º
The accuracy of the model structures is measured by TM-score, which is equal to 1 if there is a perfect match to the experimental structure.
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The smallest of the URFs is URFA
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The enthalpy of hydrogen bond formation between the nucleoside bases 2-deoxyguanosine (dG) and 2-deoxycytidine (dC) has been determined by direct measurement.
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We have directly measured the enthalpy of hydrogen bond formation between the nucleoside bases 2-deoxyguanosine (dG) and 2-deoxycytidine (dC).
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The enthalpy of hydrogen bond formation between the nucleoside bases 2-deoxyguanosine (dG) and 2-deoxycytidine (dC) has been determined by direct measurement. dG and dC were derivatized at the 5 and 3 hydroxylith triisopropylsilyl groups to obtain solubility of the nucleosides in non-aqueous solventsand(sw)to prevent the ribose hydroxyls from forming hydrogen bonds. From isoperibolic titration measurements, the enthalpy of dC:dG base pair formation is -6.650.32 kcal/mol.
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We have directly measured the enthalpy of hydrogen bond formation between the nucleoside bases 2-deoxyguanosine (dG) and 2-deoxycytidine (dC). dG and dC were derivatized at the 5 and 3 hydroxyls with triisopropylsilyl groups; these groups serve both to solubilize the nuclides in non-aqueous solvents and to prevent the ribose hydroxyls from forminghydrogenbond(eos)s. The enthalpy of dC:dG base pair formation is -6.650.32 kcal/mol according to isoperibolic titration measurements,
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Large earthquakes along a given fault segment do not occur at random intervals because it takes time to accumulate the strain energy for the rupture. The rates at which tectonic plates move and accumulate strain at their boundaries are approximately uniform. Therefore, in first approximation, one may expect that large ruptures of the same fault segment will occur at approximately constant time intervals. If subsequent main shocks have different amounts of slipacross the fault, then the recurrence time may vary, and the basic idea of periodic main shocks must be modified.
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Large earthquakes along a given fault segment do not occur at random intervals because it takes time to accumulate the strain energy for the rupture. The rates of strain accumulation at the boundaries of tectonic plates are approximately uniform. Therefore, nearly constant time interval(at first approximation) would be expected between large ruptures of the same fault segment.(s)[However?], the recurrence time may vary; the basic idea of periodic main shocks may need to be modified if subsequent main shocks have different amounts of slip across the fault.
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